There is not much Public Transportation available to travel to the center.
If you are flying in, take a New York Bus Service to New York's Pennsylvania Station. From Penn Station, you must go to 42nd Street and 7th Avenue, Port Authority Bus Terminal (Penn Station is on 34th and 7th Avenue). Take the Short Line to Binghamton or, preferably, Greene, NY.
It is possible to take the AirTrain and then the "E" train to Penn Station, but it is not advisable if you have a lot of luggage and are travelling during the week.
The following arrival destinations are serviced by the taxi/car service to the Center:
Greene, NY bus stop (closest to the center)
Binghamton Greyhound bus station
Binghamton Shortline bus station
Binghamton Airport
Retreatants need to obtain their own transportation to the center. Checker Car Services (607) 722-2227 with Palyul Center Group rate (likely increased due to gas prices). Each car can be shared by up to 4 people.